Following oral atenolol absorbed from the gastrointestinal tract by 40-50%. After ingestion of the primobolan depot the maximum plasma concentration is reached 2-4 hours.
Atenolol primobolan depot undergoes no significant hepatic metabolism, and over 90% of absorbed drug enters the systemic circulation intact. The half-life – about 6 hours, but can be increased in cases of severe renal insufficiency, because the selection of the drug occurs primarily through the kidneys. Atenolol poorly penetrates the tissue because of its low solubility primobolan side effects in lipids, and its concentration in the brain tissue is low. Communication with a minor plasma protein (about – 3%). After ingestion chlorthalidone absorbed from the gastrointestinal tract by 60%, the maximum plasma concentration is observed after about 12 hours after ingestion of the drug. The half – about 50 hours, and excretion occurs mainly kidneys turn. Chlorthalidone binds to plasma protein by about 75%. The simultaneous use of atenolol and chlorthalidone has little effect on the pharmacokinetics of each. Tenoretik effective for at least 24 hours after oral administration of single daily doses.
- hypersensitivity to any component of the drug
- bradycardia; cardiogenic shock; severe hypotension; metabolic acidosis; The expressed disturbances of peripheral circulation; atrioventricular block II and III degree; sick sinus syndrome; untreated pheochromocytoma; Chronic heart failure primobolan in a decompensation stage
- age of 18 years (effectiveness and safety have been established)Precautions: atrioventricular block I degree, Prinzmetal angina, severe bradycardia (.. Heart rate less than 60 beats / min), disorders of water and electrolyte balance of blood, advanced age, impaired renal function, bronchial asthma (a history), chronic obstructive pulmonary disease primobolan depot, hyperthyroidism, diabetes mellitus.Pregnancy and lactation Tenoretik should not be given to pregnant or lactating.DOSAGE AND ADMINISTRATION Adults 1 tablet per day. Most hypertensive patients use one tablet methenolone enanthate per day Tenoretika gives satisfactory results. Increasing the dose is not effective, if necessary, can be further assigned to other antihypertensive agents, such as a vasodilator. Elderly patients for this age group often require a lower dose of the drug (atenolol), which is determined by the attending physician.Patients with renal impairment Caution should be exercised in patients with primobolan depot impaired renal function. In patients with creatinine clearance (less than 35 ml / min), the drug can be used only after titration of the individual components of the drug.